Elevated doses of acetaminophen are toxic because an oxidized metabolite reacts with and depletes which of the following compounds that normally protects the liver and other vital organs?
A) glutathione
B) cGMP
C) plasma albumin
D) vyclooxygenase I
E) cytochrome P450

Question

Quizplus · Accepted Answer

Acetaminophen at elevated doses produces a toxic metabolite that depletes glutathione, a critical antioxidant that protects cells, particularly in the liver, from damage.

Elevated Doses of Acetaminophen Are Toxic Because an Oxidized Metabolite