Successful drugs have been discovered by which of the following methods?
A) chance observation of a beneficial, though unplanned, physiological effect
B) screening natural products with interesting activities
C) combinatorial chemical synthesis of large collections of chemically related compounds for screening
D) if the structure of the target is known, computer-aided design of compounds that might bind to the target
E) All of the answers are correct.

Question

Quizplus · Accepted Answer

All the methods listed (A through D) have been successfully used in drug discovery. Chance observations have led to the discovery of some drugs, natural products have historically been a rich source of new drugs, combinatorial chemistry has expanded the possibilities for synthetic compounds, and computer-aided design has become increasingly important as our understanding of molecular targets improves.

Successful Drugs Have Been Discovered by Which of the Following