The mechanism by which type I topoisomerase relaxes DNA includes which of the following?
A) The OH of Tyr 723 attacks a phosphate group on one DNA strand.
B) When the backbone of one strand is cleaved, the DNA rotates.
C) ATP binds, leading to a conformation change.
D) All the answers are correct.
E) The OH of Tyr 723 attacks a phosphate group on one DNA strand, and when the backbone of one strand is cleaved, the DNA rotates.
Correct Answer:
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