How can the leading and lagging strands be synthesized in a coordinated fashion?
A) Specific enzymes control the size of the DNA opening.
B) Lagging-strand binding proteins inhibit leading-strand replication if the strands become disproportionate in size.
C) DNA polymerase III is a dimeric holoenzyme, and the looped lagging strand allows the enzyme to proceed in the same direction with each strand.
D) Leading and lagging strand syntheses are catalyzed by two distinct and noninteracting replisomes, but the rate is controlled by helicase.
E) None of the answers is correct.

Question

Quizplus · Accepted Answer

DNA polymerase III, as a dimeric holoenzyme, works on both the leading and lagging strands simultaneously. The lagging strand forms a loop, enabling both strands to be synthesized in the same direction, ensuring coordination.

How Can the Leading and Lagging Strands Be Synthesized in a Coordinated