Excess alcohol consumption can lead to Wernicke-Korsaff syndrome due to the lack of the vitamin thiamine. Which of the following metabolic conversions CANNOT occur in the absence of thiamine? A) pyruvate + CO₂$\rightarrow$oxaloacetate B) pyruvate $\rightarrow$ acetyl-CoA + CO₂ C) $\alpha$-ketoglutarate $\rightarrow$succinyl-CoA + CO₂ D) phosphoenolpyruvate + CO₂$\rightarrow$ oxaloacetate E) B and C are correct.

Question

Quizplus · Accepted Answer

Thiamine is a cofactor for the enzymes that catalyze the conversion of pyruvate to acetyl-CoA and α-ketoglutarate to succinyl-CoA, making options B and C correct.

Excess Alcohol Consumption Can Lead to Wernicke-Korsaff Syndrome Due to the Lack