How is specificity determined by chymotrypsin?
A) interaction of the active site amino acids with the substrate
B) binding of the N-terminus amino acid at the active site
C) covalent binding of a His residue to the substrate
D) large conformational change of a P-loop upon binding of substrate
E) binding of the proper amino acid into a deep pocket on the enzyme

Question

Quizplus · Accepted Answer

Chymotrypsin determines specificity by binding the proper amino acid into a deep hydrophobic pocket, known as the S1 pocket, which accommodates aromatic side chains of the substrate.

How Is Specificity Determined by Chymotrypsin