What condition results from a single point mutation of the hemoglobin $\beta$ chain, producing the HbS variant?
A) $\alpha$-thalassemia
B) $\beta$-thalassemia
C) hemoglobin SC disease
D) hemolytic anemia
E) sickle-cell anemia

Question

Quizplus · Accepted Answer

Sickle-cell anemia results from a single point mutation in the beta chain of hemoglobin, which produces the hemoglobin S (HbS) variant. This mutation leads to the formation of abnormal hemoglobin molecules that can cause red blood cells to assume a sickle shape under certain conditions.

What Condition Results from a Single Point Mutation of the Hemoglobin