What would be the expected result of a Lys residue being replaced by a Ser residue in the BPG binding site of hemoglobin?
A) BPG would bind tighter because of the loss of a positive charge.
B) BPG would bind tighter because of the gain of a positive charge.
C) BPG would bind less tightly because of the loss of a positive charge
D) BPG would bind less tightly because of the gain of a positive charge.
E) This substitution would have no effect on the binding of BPG.

Question

Quizplus · Accepted Answer

BPG binds to hemoglobin through electrostatic interactions with positively charged residues. Replacing a Lys (which is positively charged) with a Ser (which has no charge) would reduce the strength of these interactions, leading to less tight binding of BPG.

What Would Be the Expected Result of a Lys Residue