Of the Following Women, Who Is the Best Candidate for Hormone

Of the following women, who is the best candidate for hormone replacement therapy?

A) Karina, a seventy year old, who hasn't menstruated since she was forty five
B) Sophie, a forty two year old, who is just beginning to experience menopause
C) Jessica, a sixty year old, who has a family history of breast cancer
D) Melissa, a sixty five year old, who has hypertension and arteriosclerosis