In the United States, the most severe genetic disease of childhood based on the number of people affected and fatality is:

Name: In the United States, the most severe genetic disease of childhood based on the number of people affected and fatality is:
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Cystic fibrosis is the most common fatal genetic disease in the United States, affecting approximately 30,000 children and adults. It is characterized by the production of thick, sticky mucus that can clog the lungs and obstruct the pancreas.

In the United States, the Most Severe Genetic Disease of Childhood