What Major Pathologic and Structural Changes Are Associated with Asbestosis

What major pathologic and structural changes are associated with asbestosis?
1) Fibrocalcific pleural plaques
2) Excessive bronchial secretions
3) Bronchospasm
4) Mediastinal shift

A) 1, 3
B) 2, 4
C) 1, 2, 3
D) 2, 3, 4