Which of the Following Statements Accurately Describes the Anatomic Alterations

Which of the following statements accurately describes the anatomic alterations of the lungs associated with emphysema?
1) It is the weakening and permanent enlargement of the air spaces distal to the terminal bronchioles.
2) It is most closely associated with cystic fibrosis.
3) The distal airways tend to collapse during expiration in response to increased intrapleural pressure.
4) It is characterized by thick secretions and mucus plugging.

A) 2, 4
B) 3, 4
C) 1, 3
D) 1, 2, 4