If You Have the Capability of Stimulating Either the Release

If you have the capability of stimulating either the release of long-lasting endogenous opiates or shorter lasting enkephalins, why would it be most prudent to stimulate the enkephalins first?

A) Stimulating enkephalins first would encourage the patient to let you use electrical stimulation.
B) It wouldn't be prudent; you should stimulate the release of the longer lasting endogenous opiates first.
C) Both will be stimulated simultaneously; there is no selective stimulation option.
D) The statement is false; you do not have this ability to stimulate either.