Physiological Changes in Response to Heat Application Vary According to the Intensity

Physiological changes in response to heat application vary according to the intensity of the agent, the duration of application, and the area being treated. Hyperemia is a sign of vigorous heating. At what tissue temperature would there be irreversible tissue damage due to protein being denatured?

A) 45^oC (113^oF)
B) 43^oC (109^oF)
C) 37^oC (98.6^oF)
D) 38^oC (100^oF)