Which of the Following Uses of Pesticide Can Lead to Ecological

Which of the following uses of pesticide can lead to ecological imbalance?

A) pesticides alter the genetic resistance in populations causing the pests to persist
B) pesticides kill prey thereby causing predators to starve or migrate. Then the prey population rebounds larger than before since predators are gone.
C) bioaccumulation of pesticides in animal tissue can lead to extinction of species.
D) pesticides show mobility, moving other than where they were applied inadvertently killing non-pest organisms.
E) All of the above