The enzyme phosphofructokinase (PFK) catalyzes a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Given its critical role in glycolysis, which of the following conditions would be a likely consequence for dogs afflicted with this disorder?
A) They would die as embryos.
B) They would have elevated blood-glucose levels, which may result in a high incidence of diabetes.
C) They would be lethargic and readily tire from exercise.
D) They would carry out elevated levels of oxidative phosphorylation.

Question

Quizplus · Accepted Answer

Since PFK is a key enzyme in glycolysis, its deficiency would impair the production of ATP via anaerobic respiration. This would result in limited energy availability for cells, causing affected dogs to exhibit lethargy and fatigue during exercise.

The Enzyme Phosphofructokinase (PFK) Catalyzes a Key Step in Glycolysis