The residues in a DNA-binding protein that interact with DNA usually correspond to each other according to the amino acids encoded by the DNA. For example, a DNA sequence containing AGC-AGA-CAG which encodes for Ser-Arg-Gln would likely have a DNA-binding protein with the sequence Ser-Arg-Gln.

Question

Quizplus · Accepted Answer

The residues in a DNA-binding protein that interact with DNA do not necessarily correspond to the amino acids encoded by the DNA sequence they bind to. The specificity of a DNA-binding protein for its DNA target is determined by the shape and chemical properties of the protein's DNA-binding domain, not by the amino acids encoded by the DNA sequence.

The Residues in a DNA-Binding Protein That Interact with DNA