Interaction of a pathogen-associated molecular pattern (PAMP) with a pattern recognition receptor (PRR) results in
A) formation of transmembrane pores that cause cell lysis.
B) transmembrane signal transduction that initiates transcription of genes involved in phagocytosis, inflammation, and pathogen killing.
C) molecular activation of the adaptive immune system.
D) a superantigen reaction that can cause septic shock.

Question

Quizplus · Accepted Answer

PAMPs are molecules associated with microbial pathogens that are recognized by PRRs on host cells. When a PAMP binds to a PRR, it triggers a series of intracellular events that activate signaling pathways, leading to the transcription of genes involved in host defense mechanisms such as phagocytosis, inflammation, and pathogen killing. This process is known as transmembrane signal transduction. Formation of transmembrane pores or activation of the adaptive immune system is not directly associated with PAMP-PRR interaction. Superantigen reactions occur when bacterial toxins activate T cells in a non-specific manner, and are not directly related to PAMP-PRR interaction.

Interaction of a Pathogen-Associated Molecular Pattern (PAMP) with a Pattern