The two-stage thymic selection process for selecting self-tolerant, antigen-reactive T cells results in
A) allelic exclusion.
B) clonal deletion.
C) complementarity-determining regions.
D) somatic hypermutation.

Question

Quizplus · Accepted Answer

The two stages of thymic selection are positive selection, where T cells with low affinity for self-antigens are eliminated, and negative selection, where T cells with high affinity for self-antigens are deleted via clonal deletion. This process ensures that only T cells with a good affinity for non-self antigens remain, preventing autoimmune reactions. Allelic exclusion refers to the mechanism by which only one allele of a gene is expressed in a given cell, and is not directly related to thymic selection. Complementarity-determining regions and somatic hypermutation are mechanisms related to B cell development and maturation, not T cell selection.

The Two-Stage Thymic Selection Process for Selecting Self-Tolerant, Antigen-Reactive T