Amino acid variability is especially apparent in several ________ in the variable domains of different immunoglobulins.
A) heavy chains
B) complementarity-determining regions (CDR)
C) peptide motifs
D) epitopes

Question

Quizplus · Accepted Answer

The complementarity-determining regions (CDR) are the variable domains of different immunoglobulins that exhibit a high level of amino acid variability, which is essential for the recognition and binding of diverse epitopes. The heavy chains also contribute to the variable region variability, but it is primarily the CDR that is responsible for the diversity in the binding specificity of antibodies. Peptide motifs and epitopes are not regions of the immunoglobulin but rather the sequences that are recognized by the immunoglobulin.

Amino Acid Variability Is Especially Apparent in Several ________ in the Variable