Staphylococcus aureus and Streptococcus pyogenes produce exotoxins known as superantigens that bind to a site on the TCR that is outside the antigen-specific TCR binding site.

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Staphylococcus aureus and Streptococcus pyogenes produce exotoxins known as superantigens that bind to a site on the TCR that is outside the antigen-specific TCR binding site. This can lead to massive activation of T cells and potentially harmful immune responses.

Staphylococcus Aureus and Streptococcus Pyogenes Produce Exotoxins Known as Superantigens