Systemic fungal infections are difficult to treat because active antifungal drugs may have significant host toxicity.

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Systemic fungal infections are challenging to treat because antifungal drugs that are active against them can also have significant toxicity to the patient. This can lead to side effects such as liver damage, kidney damage, and bone marrow suppression. Therefore, the choice of antifungal therapy must be carefully weighed against the potential benefits and risks for the individual patient.

Systemic Fungal Infections Are Difficult to Treat Because Active Antifungal