The TCA cycle must "turn twice" in order to complete the oxidation of one glucose molecule.

Question

Quizplus · Accepted Answer

This is true because the TCA cycle begins with the entry of acetyl-CoA, which is produced from the breakdown of one glucose molecule via glycolysis and pyruvate oxidation. The acetyl-CoA enters the TCA cycle and is oxidized, producing energy and reducing agents that will be used in the electron transport chain. However, since the breakdown of one glucose molecule yields two molecules of pyruvate, each of which produces one molecule of acetyl-CoA, the TCA cycle must turn twice in order to fully oxidize the two molecules of acetyl-CoA produced from one glucose molecule.

The TCA Cycle Must "Turn Twice" in Order to Complete