Please Select the True Statement Regarding Bacterial Resistance to Antimicrobials

Please select the True statement regarding bacterial resistance to antimicrobials.

A) Gram-positive bacteria are intrinsically resistant to certain medications because the lipid bilayer of their outer membrane prevents the molecules from entering.
B) Intrinsic resistance  generally occurs through spontaneous mutation or horizontal gene transfer.
C) The genes for antimicrobial resistance are often carried on fertility plasmids (F plasmids) .
D) Mycoplasma species lack a cell wall, so they are resistant to penicillin that interferes with peptidoglycan synthesis. This is an example of intrinsic resistance.
E) Acquired resistance is very limited because microorganisms cannot evolve, so are incapable of developing mechanisms to avoid the effects of medications.