Please Select the False Statement Regarding Antibiotic Resistance

Please select the False statement regarding antibiotic resistance.

A) Modifications in the penicillin-binding proteins (PBPs) prevent β-lactam antibiotics from binding to them.
B) Some antibiotic-inactivating enzymes have an extended spectrum and confer resistance to a wide variety of antibiotics.
C) Changes in the porin proteins can prevent certain antimicrobials from entering a cell's periplasm or cytoplasm.
D) The bacterial enzyme chloramphenicol acetyltransferase confers resistance to the penicillins.
E) Bacteria that produce efflux pumps sometimes become resistant to several different antimicrobials simultaneously.