Fluoroquinolones Act by Inhibiting DNA Gyrase, an Enzyme Involved in DNA

Fluoroquinolones act by inhibiting DNA gyrase, an enzyme involved in DNA replication. Resistance to this antibiotic is most commonly by

A) a change in the DNA gyrase target, an example of acquired resistance.
B) enzymatic modification of the ribosomal target, an example of innate resistance.
C) a change in the DNA gyrase target, an example of innate resistance.
D) due to a mutation in the gene that encodes RNA polymerase, an example of adaptive resistance.
E) increased efflux of the drug from the target cell, an example of innate resistance.