A nucleoside analog can be phosphorylated in vivo by a virally encoded or normal cellular enzyme to form a nucleotide analog-a chemical structurally similar to the building blocks of DNA and RNA. Nucleotide analogs interfere with

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Nucleotide analogs, by interfering with the synthesis of viral nucleic acids, can prevent viral replication and thus reduce the viral load. Nucleotide analogs are incorporated into the growing viral DNA chain and cause premature termination of the chain, ultimately inhibiting viral replication.

A Nucleoside Analog Can Be Phosphorylated in Vivo by a Virally