Why are there currently no vaccines against Streptococcus pyogenes?
A) There are many antigenic types in the M protein of this organism. A vaccine against one type might not protect against another.
B) There is great variation in the polysaccharide capsule of this organism. A vaccine against one type might not protect against another.
C) Antibodies to streptococcal M protein may also recognize and bind to myosin in the heart, causing autoimmunity and leading to rheumatic fever.
D) There is great variation in the M protein of this organism. A vaccine against one M type might not protect against another AND antibodies to streptococcal M protein may also recognize and bind to myosin in the heart, causing autoimmunity and leading to rheumatic fever.
E) There is great variation in the polysaccharide capsule of this organism. A vaccine against one type might not protect against another AND antibodies to streptococcal M protein may also recognize and bind to myosin in the heart, causing autoimmunity and leading to rheumatic fever.
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