Why does the rash of shingles occur in only a limited region, as opposed to the widespread rash of chickenpox?
A) In chickenpox, the replicating virus originates from multiple infected nerve cells, while in shingles it is limited to the bloodstream.
B) In shingles, the replicating virus originates from a single infected nerve cell, while in chickenpox it is spread throughout the bloodstream.
C) In chickenpox, the virus spreads through the bloodstream to all parts of the body, while in shingles, the virus remains in the chest area after inhalation.
D) The chickenpox virus is a double-stranded DNA virus that is able to infect any nucleated cells, while the shingles virus is a single-stranded RNA virus that only infects epidermal cells.
E) This question is misleading because the rash of both chickenpox and shingles is widespread throughout the body.

Question

Quizplus · Accepted Answer

The rash in chickenpox occurs due to virus replication throughout the bloodstream, leading to widespread distribution of the virus and resulting rash. In contrast, the replication of the shingles virus is limited to a single nerve cell and its progeny, resulting in a localized distribution of the rash.

Why Does the Rash of Shingles Occur in Only a Limited