What Is NOT a Reason Why an Abscessed Wound Might

What is NOT a reason why an abscessed wound might not respond to antibiotic treatment?

A) The bacteria within the abscess have stopped replicating, and many antibiotics require actively replicating cells in order to be effective.
B) The blood vessels that would bring the drug to the area have been destroyed or have clots, preventing the drug from getting to the microbes.
C) The chemical composition of the pus in the abscess often inactivates antibiotics, making them ineffective.
D) These are all reasons that it might be difficult to treat an abscess.
E) The bacteria in an abscess always acquire multi-drug antibiotic resistance, so any drugs that are used will have no effect.