The development of lymph node enlargement in the region of a skin ulcer after a tick or insect bite or handling of a wild animal suggests

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The development of lymph node enlargement in the region of a skin ulcer after a tick or insect bite or handling of a wild animal is typical of tularemia, a bacterial infection caused by Francisella tularensis. The disease can also cause fever, headache, fatigue, and other flu-like symptoms. Other options like brucellosis, endocarditis, sepsis, and Lyme disease do not typically present with lymphadenopathy in this manner.

The Development of Lymph Node Enlargement in the Region of a Skin