What Leads to Organ Failure in Sepsis

What leads to organ failure in sepsis?

A) Uncontrolled inflammation that leads to neutrohpils releasing damaging toxins and lysosomal enzymes.
B) Helper T cells and dendritic cells undergo apoptosis, causing immunosuppression that results in organ rejection.
C) Formation of small clots in capillaries, impairing blood flow to organs and causing hypoxia and cell death.
D) Accumulation of endotoxins released from Gram-negative bacteria in the organs, causing tissue damage and cell death.
E) Organisms from an infected site generate biofilms that break apart, leading to emboli and organ destruction.