Which Statement About Infectious Mononucleosis Is False

Which statement about infectious mononucleosis is False?

A) Initial signs and symptoms of EBV infection resemble those of pharyngitis.
B) In a non-productive EBV infection, the virus establishes a latent infection and is maintained as either a plasmid or a provirus.
C) EBV-infected B cells produce a heterophile antibody that plays no role in the pathology of mononucleosis, but can be used for diagnosis.
D) Infectious mononucleosis results in lymph node and spleen enlargement, and is occasionally fatal because the spleen may rupture.
E) Antiviral medications such as acyclovir and famciclovir inhibit both productive and non-productive EBV infections.