You are reviewing for your nursing school entry exam with your study group. Each person in the group agrees to cover one disease. You select toxoplasmosis for your presentation. Toxoplasmosis can be a serious problem for those who are immunosuppressed, as well as for fetuses. Even in healthy people, the immune system may not clear the organism, resulting in a latent infection that can reactivate when immunity declines.
-Please identify the correct sequence of events in the pathogenesis of toxoplasmosis.
1) Each cyst contains large numbers of bradyzoites, a smaller form of T. gondii which persists in a latent infection.
2) As host immunity develops, a tough, fibrous capsule forms around infected host cells, forming a tissue cyst.
3) Within the small intestinal cells, sporozoites develop rapidly into tachyzoites which spread systemically.
4) T. gondii enters the host when either mature oocysts containing two sporocysts are eaten.
5) Sporozoites emerge from each of the sporocysts, and invade the cells of the small intestine.
A) 4, 5, 3, 2, 1
B) 1, 2, 4, 3, 5
C) 3, 2, 1, 4, 5
D) 2, 4, 5, 1, 3
E) 1, 5, 4, 2, 3

Question

You are reviewing for your nursing school entry exam with your study group. Each person in the group agrees to cover one disease. You select toxoplasmosis for your presentation. Toxoplasmosis can be a serious problem for those who are immunosuppressed, as well as for fetuses. Even in healthy people, the immune system may not clear the organism, resulting in a latent infection that can reactivate when immunity declines.
-Please identify the correct sequence of events in the pathogenesis of toxoplasmosis.
1) Each cyst contains large numbers of bradyzoites, a smaller form of T. gondii which persists in a latent infection.
2) As host immunity develops, a tough, fibrous capsule forms around infected host cells, forming a tissue cyst.
3) Within the small intestinal cells, sporozoites develop rapidly into tachyzoites which spread systemically.
4) T. gondii enters the host when either mature oocysts containing two sporocysts are eaten.
5) Sporozoites emerge from each of the sporocysts, and invade the cells of the small intestine.
A) 4, 5, 3, 2, 1
B) 1, 2, 4, 3, 5
C) 3, 2, 1, 4, 5
D) 2, 4, 5, 1, 3
E) 1, 5, 4, 2, 3

Quizplus · Accepted Answer

The correct sequence starts with the ingestion of mature oocysts (4), followed by the release of sporozoites into the small intestine (5), which then develop into tachyzoites and spread throughout the body (3). As the host's immune system responds, a fibrous capsule forms around infected cells, creating a tissue cyst (2), and within these cysts, bradyzoites persist in a latent infection (1).

You Are Reviewing for Your Nursing School Entry Exam with Your