The most significant etiology for chronic obstructive pulmonary disease (COPD) is:

Name: The most significant etiology for chronic obstructive pulmonary disease (COPD) is:
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Tobacco use or exposure is the most significant etiology for COPD and accounts for 80% to 90% of all cases of COPD. Exposure to certain chemicals in the work environment may be a causative factor of COPD but is not as significant as tobacco. COPD includes emphysema and chronic bronchitis.

The Most Significant Etiology for Chronic Obstructive Pulmonary Disease (COPD)