Robert Whytt's 1751 publication On the Vital and Other Involuntary Motions of Animals suggests that the principle of sentience is the force behind an organism's response to stimuli.This was an important finding because

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Robert Whytt's work offered an alternative to Cartesian dualism by suggesting that sentience, rather than just mechanical reactions or divine intervention, played a key role in how organisms respond to stimuli. This was significant in the context of the mind-body debate, as it introduced a nuanced view that bridged the gap between purely physical and purely mental explanations for bodily movements.

Robert Whytt's 1751 Publication on the Vital and Other Involuntary