What is an example of a pharmacogenetic factor that may affect the efficacy of antidepressant drugs?

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The shorter variation of a serotonin transporter gene (often referred to as the "short allele" of the 5-HTTLPR gene) is a well-documented pharmacogenetic factor that can affect the efficacy of antidepressant drugs, particularly those that target the serotonin system, such as SSRIs (Selective Serotonin Reuptake Inhibitors). This genetic variation can influence how individuals respond to these medications, with some studies suggesting that individuals with one or two copies of the short allele may not respond as well to SSRIs as those with two long alleles.

What Is an Example of a Pharmacogenetic Factor That May