Which statement best reflects the relationship between the ORL-1 receptor and other opioid receptors?
A) ORL-1 receptor effects are unrelated to those of other opioid receptors.
B) ORL-1 receptor effects are redundant to those of other opioid receptors.
C) ORL-1 receptor effects strengthen those of other opioid receptors.
D) ORL-1 receptor effects oppose those of other opioid receptors.

Question

Quizplus · Accepted Answer

The ORL-1 receptor, which binds the endogenous peptide nociceptin/orphanin FQ, has effects that are generally considered to oppose those of other opioid receptors like the mu, delta, and kappa receptors. This opposition can be seen in terms of nociceptin's ability to modulate pain, stress, and addiction pathways differently from classical opioids.

Which Statement Best Reflects the Relationship Between the ORL-1 Receptor