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A Key Form of Psychostimulant Tolerance Is Pharmacodynamic Tolerance, Caused

Question 48

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A key form of psychostimulant tolerance is pharmacodynamic tolerance, caused in part by changes in dopamine D2 receptor sensitivity. Describe the study by Barrett and colleagues (1992) demonstrating a link between D2 receptors and repeated psychostimulant administration. Include in your answer a description of the experiments used in the study and an analysis of the results.

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Barrett and colleagues (1992) demonstrat...

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