Glutamate's NMDA-receptor is activated in response to the binding of glutamate. However, the NMDA receptor also requires D-serine to be tightly bound on a distant receptor site. Without bound D-serine, glutamate cannot activate NMDA receptors. The site to which D-serine binds is referred to as a(n) ____ site.

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The site to which D-serine binds is referred to as an allosteric site because it is a different location from the primary active site (where glutamate binds) and its binding influences the activity of the receptor indirectly.

Glutamate's NMDA-Receptor Is Activated in Response to the Binding of Glutamate