Dr. Engle is a toxicologist at the pharmaceutical company Pharma Giant. He wants to calculate a conservative value for his therapeutic index. Which formula should he use?

Question

Quizplus · Accepted Answer

The therapeutic index is calculated as the ratio of the lethal dose (LD50) to the effective dose (ED50), where LD50 is the dose lethal to 50% of the population and ED50 is the dose effective in 50% of the population. A conservative value for the therapeutic index would use LD50 (lethal dose for 50% of the population) in the numerator and ED50 (effective dose for 50% of the population) in the denominator, making choice A correct.

Dr Engle Is a Toxicologist at the Pharmaceutical Company Pharma