Which of the Following Is Required for Effective Use of Pharmacogenomics

Which of the following is required for effective use of pharmacogenomics in predicting outcomes of drug therapy?

A) An understanding of how the drug is metabolized
B) An understanding of how the genetic variation influences the drug's pharmacokinetics
C) An understanding of how the genetic variation influences the drug's pharmacodynamics
D) High positive predictive value for the test
E) All of the above