Which of the following is associated with gene amplification of protooncogenes?

Question

Quizplus · Accepted Answer

Gene amplification of protooncogenes is associated with homogeneously stained regions (HSRs) and double minute chromosomes (DMs). HSRs are areas within chromosomes that stain uniformly, indicating gene amplification at that location. Double minute chromosomes are small, extrachromosomal fragments that also indicate gene amplification. Microsatellite instability, on the other hand, is associated with mismatch repair defects and is not directly related to gene amplification.

Which of the Following Is Associated with Gene Amplification of Protooncogenes