Approximately 50% of patients with homocystinuria caused by cystathionine-synthase deficiency respond to treatment with which vitamin, the precursor to this enzyme's cofactor?

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Vitamin B6 (pyridoxine) is the precursor to pyridoxal phosphate, which is the cofactor for the enzyme cystathionine beta-synthase. Approximately 50% of patients with homocystinuria due to cystathionine-synthase deficiency respond to high doses of vitamin B6.

Approximately 50% of Patients with Homocystinuria Caused by Cystathionine-Synthase Deficiency