Which of the Following Properties Allows Enzyme Replacement Therapy to Work

Which of the following properties allows enzyme replacement therapy to work for some lysosomal storage disorders?

A) Excess enzyme causes formation of new lysosomes
B) The enzymes can be dried into a pill
C) The enzymatic defect is generally mild
D) Cells can take up the enzymes from extracellular fluid
E) The therapy triggers upregulation of the deficient enzyme