What Common Effect Do Mutations That Are Associated with Monogenic $\beta$

What common effect do mutations that are associated with monogenic forms of Alzheimer disease typically have?

A) Increased production of Tau
B) Increased production of amyloid precursor protein
C) Decreased production of amyloid precursor protein
D) Increased production of A $\beta$ ₄₂ peptide
E) Decreased production of A $\beta$ ₄₂ peptide