Using the following groups, compose a formula for the odds ratio for a disease-marker association.
a. Affecteds who have marker allele of interest
b. Affecteds who lack the marker allele of interest
c. Controls who have the marker allele of interest
d. Controls who lack the marker allele of interest

Question

Using the following groups, compose a formula for the odds ratio for a disease-marker association. 
a. Affecteds who have marker allele of interest
b. Affecteds who lack the marker allele of interest
c. Controls who have the marker allele of interest
d. Controls who lack the marker allele of interest

Quizplus · Accepted Answer

The odds ratio for a disease-marker association is calculated as (a*d)/(b*c), where 'a' represents affected individuals with the marker allele, 'b' represents affected individuals without the marker allele, 'c' represents controls with the marker allele, and 'd' represents controls without the marker allele. This formula compares the odds of having the marker among the affected to the odds of having the marker among the controls.

Using the Following Groups, Compose a Formula for the Odds