Why is it believed that transitions are overrepresented among the disease-causing mutations?
A) Increased susceptibility of guanines to mutagens
B) Weaker hydrogen bonding between A-T pairs
C) Spontaneous deamination of 5-methylcytosines
D) Overrepresentation of cytosine phosphate guanine (CpG) in the genome
E) DNA repair mechanisms work less efficiently on these changes

Question

Quizplus · Accepted Answer

Spontaneous deamination of 5-methylcytosines leads to transitions, specifically converting them to thymines, which are not easily recognized and repaired by DNA repair mechanisms, thus contributing to their overrepresentation among disease-causing mutations.

Why Is It Believed That Transitions Are Overrepresented Among the Disease-Causing