Variation in which two genes is known to greatly increase the risk of venous thrombosis in women using oral contraceptives?
A) C-reactive protein and factor V
B) Factor VIII and factor IX
C) Factor IX and factor X
D) C-reactive protein and prothrombin
E) Factor V and prothrombin

Question

Quizplus · Accepted Answer

Variations in the Factor V gene (specifically Factor V Leiden mutation) and the prothrombin gene (G20210A mutation) are known to significantly increase the risk of venous thrombosis, especially in women who use oral contraceptives. These genetic variations affect the blood's ability to clot, making clot formation more likely.

Variation in Which Two Genes Is Known to Greatly Increase