What is the mechanism by which recurrent deletions associated with contiguous gene syndromes occur?

Question

Quizplus · Accepted Answer

Aberrant recombination between low copy repeats (LCRs) is a common mechanism by which deletions (and duplications) occur, leading to contiguous gene syndromes. These LCRs can misalign during meiosis, resulting in unequal crossing over and the deletion (or duplication) of the genomic material between them.

What Is the Mechanism by Which Recurrent Deletions Associated with Contiguous